Peripheral Electrical Stimulation Modulates Cortical Beta-Band Activity

Low-frequency peripheral electrical stimulation using a matrix electrode (PEMS) modulates spinal nociceptive pathways. However, the effects of this intervention on cortical oscillatory activity have not been assessed yet. The aim study was to investigate low-frequency PEMS (4 Hz) in different brain states healthy pain-free participants. In experiment 1, compared sham stimulation. 2, motor imagery (MI) used modulate sensorimotor state. applied either during MI-induced desynchronization (concurrent PEMS) or after MI (delayed cross-over design. For both experiments, left forearm and resting-state electroencephalography (EEG) recording before each condition. Experiment 1 showed significant decrease global beta power ( p = 0.016), with median change from baseline ?16% for ?0.54% sham. A cluster-based permutation test difference comparing pre- post-PEMS 0.018) that most pronounced over bilateral central frontal sensors. 2 did identify EEG concurrent delayed PEMS. Two tests suggested may be increased following This provides novel evidence supraspinal an initial indication presence cognitive task such as influence activity. Chronic pain has associated changes activity, particular increase regions. Thus, state-dependent offer approach treatment chronic pain. further studies are warranted optimal conditions achieve reduction